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gpt-6THREAD

Astra tops antibody developability prediction benchmark

The author says GPT-6 Astra outperforms other frontier models on their antibody developability benchmark, and an interactive visualization of how antibodies work was built with it in about an hour.

Andrew Aiginin
@andrewaigininArchived 2026.09.14Originally posted 2026.09.10
THREADPosted in 2 parts
  1. GPT-6 Astra is now the best-performing frontier model for antibody developability prediction in our benchmark. 🧬 Finding an antibody that binds is only the beginning. Will it aggregate? Will it stay stable? Can it actually behave like a drug? GPT-6 Astra predicts these developability properties better than the other frontier models we tested. 🤯 And yes, the interactive visualization showing how an antibody actually works was also built with Astra in about 1 hour. This model looks seriously powerful. Congrats @gbt @sama #insilicoSOTAFM

  2. We checked the Insilico Score in our DDD Benchmark. GPT-6 Astra scored 37.98, calculated as the mean performance across 6 antibody developability assays. 🧪 Great work on the new model, @thekaransinghal @joyjiao12 @maggie_hott 👏

Andrew Aiginin @andrewaigininOriginally posted 2026.09.10
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x.com/andrewaiginin/status/2098078245350518884Archived 2026.09.14 15:48