Astra leads on multi-step retrosynthesis benchmark

Vladimir Aladinskiy @VladAladinOriginally posted 2026.09.12

Open original on X

GPT-6 Astra is the best frontier model for multi-step retrosynthesis. 🧪 In our DDD Benchmark, it outperformed every other frontier model we tested, coming remarkably close to specialist-level models for synthesis planning. Our Rentosertib molecule, which showed an age-reversing effect across 6 aging clocks in Phase 2 clinical trials, also had to be synthesized somehow. 😅 And that’s exactly what we measure here: how well a model can predict synthetic routes for small molecules. Great job @sama, @gdb 👏 #insilicoSOTAFM