Codex 里用 Boltz 做 GFP 蛋白 in-painting 并让 Astra 出片

Jacob @JacobMolBio原推发布于 2026.09.15

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Protein in-painting test in Codex Rosalind Workbench using Boltz A section of GFP was masked out and replaced with an ALFA nanobody tag. Newly generated sequences flanking the tag were guided by the shape of the GFP barrel. After, Bytedance's Protenix and Apple's SimpleFold were used as two extra structural “checks”. Meaning, after Boltz took care of the in-painting, the resulting sequences were fed into Protenix and SimpleFold just to see how those structures compared to the Boltz-generated structures, and how all of these compared to WT GFP. GPT 6 Astra then made a video on the workflow

这条是引用着另一条写的：x.com/junioryu136689/status/2098674359397486769